Hypothesis: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19.
Identifieur interne : 000682 ( Main/Exploration ); précédent : 000681; suivant : 000683Hypothesis: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19.
Auteurs : James H. Diaz [États-Unis]Source :
- Journal of travel medicine [ 1708-8305 ] ; 2020.
Abstract
Intravenous infusions of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in experimental animals increase the numbers of angiotensin-converting enzyme 2 (ACE2) receptors in the cardiopulmonary circulation. ACE2 receptors serve as binding sites for SARS-CoV-2 virions in the lungs. Patients who take ACEIs and ARBS may be at increased risk of severe disease outcomes due to SARS-CoV-2 infections.
DOI: 10.1093/jtm/taaa041
PubMed: 32186711
Affiliations:
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